Moxonidine: a review

Moxonidine: Clinical Profile

Acute poisoning with moxonidine? A case report.

The effects of moxonidine, a novel imidazoline, on plasma norepinephrine in patients with congestive heart failure. Moxonidine Investigators.

OBJECTIVE To evaluate the dose response relationship of moxonidine on plasma concentration of norepinephrine during acute and chronic administration in patients with congestive heart failure (CHF). BACKGROUND Sympathetic activation is increased in heart failure. Moxonidine is an imidazoline ligand acting on the central nervous system (CNS) receptors to decrease sympathetic activation. METHO...

Rare psychotropic adverse event of moxonidine.

Moxonidine is a centrally acting antihypertensive agent with high affinity to the imidazolinI1 receptor which induces peripheral sympathetic inhibition reflected by lowering of blood pressure and heart rate (Ernsberger et al. 1993). To a lesser extent it also binds to the α2-receptors whose activation is responsible for side-effects of central antihypertensive drugs such as sedation and dry mou...

Metabolism and disposition of moxonidine in Fischer 344 rats.

The metabolism and disposition of moxonidine (4-chloro-5-(imidazolidin-2-ylidenimino)-6-methoxy-2-methylp yrimidine ), a potent central-acting antihypertensive agent, were investigated in F344 rats. After an i.v. or oral administration of 0.3 mg/kg of [(14)C]moxonidine, the maximum plasma concentrations of moxonidine were determined to be 146.0 and 4.0 ng/ml, respectively, and the elimination h...